Cetacaine Spray is a fast-acting, long-lasting, prescription topical anesthetic. Cetacaine is the only topical anesthetic with three active ingredients. Cetacaine has been safely used by practitioners for over 50 years. Cetacaine controls pain, eases discomfort and suppresses the gag reflex, thus providing patient cooperation. Caution: United States federal law prohibits dispensing without a prescription. Do not use in the eyesnot for prolonged use.